Send me the course. How to Take Recommended dosage, active amounts, other details. Easily stay on top of the latest nutrition research Become an Examine Member to get access to the latest research. Get instant access — start your free day trial Already a Member? Click here to log in. Full details are available to Examine Members. Not a Member? Try Examine Membership completely free for two weeks. Grade Level of Evidence [show legend] Robust research conducted with repeated double-blind clinical trials Multiple studies where at least two are double-blind and placebo controlled Single double-blind study or multiple cohort studies Uncontrolled or observational studies only.
Level of Evidence? The amount of high quality evidence. The more evidence, the more we can trust the results. The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect. Scientific research does not always agree. In otherwise healthy males, testosterone is not influenced with supplementation of tribulus terrestris. There may be an increase in infertile men, but this is weak.
There may be a small effect in postmenopausal women with low libido, however, the difference wasn't statistically significant.
Blood Pressure. A decrease in blood pressure has been noted in hypertensive subjects in one study. Another larger study in normotensive subjects failed to find a significant change. More studies in hypertensive subjects are needed before confidence in the effect is warranted. The effect is reliable across all studies so far, however, research is still in its early stage and great confidence in these results would be unwarranted.
Heart Rate. A decrease in heart rate has been observed in hypertensive persons given tribulus supplementation. Most studies found an improvement in sexual desire in women reporting a general loss of libido.
One study in men found an improvement. The research is still in its early stage and great confidence in these results would be unfounded. Exercise related fatigue and vigor is unaffected by tribulus supplementation in trained men.
Lean Mass. Insufficient evidence to support a consistent increase of lean mass associated with tribulus relative to placebo during training or in general. Luteinizing Hormone. A consistent influence on luteinizing hormone hasn't been detected with supplemental tribulus. Power Output. No significant alterations in power output associated with tribulus supplementation. Sperm Count. Only one uncontrolled trial has found an increase in sperm count with supplementation of 2.
One study found an increase but it wasn't significant, and one that used 6g of tribulus root didn't find a significant increase compared with control. Sperm Quality. The increase in sperm quality seen with 6g tribulus root has failed to outperform placebo in infertile men. Another uncontrolled study that used 2. Total cholesterol.
A decrease in cholesterol levels has been noted with tribulus supplementation in some studies. Men who pop supplements to boost testosterone, rev up libido, or even prevent cancer may not be getting what they think they're getting. A lot of American guys use dietary supplements — an estimated 47 percent — and they're spending a ton of money on them. But these billions are going for stuff that's neither FDA-regulated nor proven to be safe or effective. Supplement makers can say whatever they want about their products as long as they don't claim to prevent, cure, or treat disease.
And a man's decision to use supplements may be motivated more by wishful thinking than by hard evidence. Guys who are hopeful that supplements will bulk them up, maybe prevent disease , or, more likely, boost their bedroom performance, should be especially wary of these 7 supplements. Beta-carotene is an antioxidant responsible for the deep red-orange color found in carrots, sweet potatoes, and cantaloupe. The body converts beta-carotene into vitamin A , a fat-soluble nutrient that protects cells from damage and that we need for eye, immune system, and skin health.
It's a great example of a nutrient that in the s and s was thoroughly investigated in animal studies, and even in some human observational studies that suggested "greater amounts of beta-carotene intake would result in a lower risk of cancer," said Howard D.
However, these trials testing individual beta-carotene supplements — as well as vitamin A — offered "pretty compelling evidence that the potential benefits were not real," said Dr. Some studies even suggested an increased risk for lung cancer in people who took them, especially in men who smoke, he added.
Toxicity can result from high doses of vitamin A because the body stores rather than gets rid of excess amounts. Selenium is a trace mineral Americans usually get enough of from breads, grains, meat, poultry, and fish. It's another antioxidant that's been evaluated in high doses to see if it could protect against chronic diseases like cancer. However, "the selenium trial that was done years ago in people to prevent recurrence of skin cancer actually increased the recurrence of skin cancer," said Alan Kristal, DrPH, a faculty member in the Public Health Sciences Division at the Fred Hutchinson Cancer Research Center in Seattle.
Further analysis suggested a prostate cancer risk benefit, said Dr. Sesso, which helped propel the launch of the SELECT trial, the largest prostate cancer prevention study to date that tested the effects of selenium and vitamin E. Clinical relevance is not known. You are taking antihypertensive drugs: Tribulus may have an additional blood pressure lowering effect.
You are taking antidiabetics: Tribulus may have additive blood sugar lowering effects. You are taking clopidogrel : Tribulus may increase the risk of blood clots. Stent thrombosis has been reported in patients following concurrent use of clopidogrel and an herbal formula containing tribulus. Side Effects. Gastrointestinal irritation Case reports of severe liver, kidney, and neurological toxicities and Priapism.
For Healthcare Professionals. Scientific Name. Clinical Summary. Mechanism of Action. Adverse Reactions. Neuro-, hepatic, and renal toxicity suggestive of acute tubular necrosis ATN : In a year-old man who consumed large quantities of tribulus extract for its antiurolithiatic properties. Priapism: In a year-old Caucasian man, for 72 hours, followed by consumption of tribulus. The patient underwent a cavernoglandular shunt Ebbehoj shunt , which had negative post-episode outcomes on sexual function Herb-Drug Interactions.
Diruetics : Tribulus may increase the effects of other diuretic drugs 7. Antihypertensive drugs : Tribulus has angiotensin converting enzyme ACE -inhibition activity and therefore, may have an additional hypotensive effect 2 3. Antidiabetics : Tribulus may have additive hypoglycemic effects 8.
Clopidogrel : May increase the risk of blood clots. Stent thrombosis has been reported in patients following concurrent use of clopidogrel and an herbal formula containing tribulus P-glycoprotein P-gp substrate drugs : In vitro, saponins and phenolic compounds from Tribulus terrestris has been shown to inhibit P-gp activity. This may increase the risks of adverse effect of substrate drugs Herb Lab Interactions.
Significant elevations in serum aminotransferases and creatinine 47 , and mildly elevated alkaline phosphatase as well as aspartate and alanine aminotransferases 27 have been reported. The analgesic effect of Tribulus terrestris extract and comparison of gastric ulcerogenicity of the extract with indomethacine in animal experiments. Ann N Y Acad Sci. Jan ; Life Sci. Oct 24 ;73 23 Antihypertensive and vasodilator effects of methanolic and aqueous extracts of Tribulus terrestris in rats.
J Ethnopharmacol. Apr 6 ; 3 Evaluation of natural products on inhibition of inducible cyclooxygenase COX-2 and nitric oxide synthase iNOS in cultured mouse macrophage cells.
Nov ;83 Effect of aqueous extract of Tribulus terrestris on oxalate-induced oxidative stress in rats. Indian J Nephrol. Jul ;21 3 The protective effect of Tribulus terrestris in diabetes. Nov ; Tribulus terrestris : preliminary study of its diuretic and contractile effects and comparison with Zea mays.
Apr ;85 Hypoglycemic and hypolipidemic effects of alcoholic extract of Tribulus alatus in streptozotocin-induced diabetic rats: a comparative study with T. Indian J Exp Biol. Sep ;45 9 Antibacterial and antifungal activities of different parts of Tribulus terrestris L. J Zhejiang Univ Sci B. Feb ;9 2 In vitro and in vivo antifungal activities of the eight steroid saponins from Tribulus terrestris L. Biol Pharm Bull. Dec ;28 12 Screening of some saponins and phenolic components of Tribulus terrestris and Smilax excelsa as MDR modulators.
In Vivo. Jul-Aug ;23 4 Aqueous extract of Tribulus terrestris Linn induces cell growth arrest and apoptosis by down-regulating NF-kappaB signaling in liver cancer cells.
Jun 14 ; 1 Effects of Tribulus terrestris on endocrine sensitive organs in male and female Wistar rats. Jan 8 ; 1 Evaluation of the aphrodisiac activity of Tribulus terrestris Linn.
J Pharmacol Pharmacother. Jan ;3 1 Saponins from Tribulus terrestris L are less toxic for normal human fibroblasts than for many cancer lines: influence on apoptosis and proliferation.
Exp Biol Med Maywood. Jan ; 1 Short term impact of Tribulus terrestris intake on doping control analysis of endogenous steroids. Forensic Sci Int. Jun 10 ; 1 :e Tribulus terrestris -induced severe nephrotoxicity in a young healthy male.
Nephrol Dial Transplant. Nov ;25 11 Bourke CA. Abnormal turning behaviour, GABAergic inhibition and the degeneration of astrocytes in ovine Tribulus terrestris motor neuron disease. Aust Vet J. Jan-Feb ;84 Chemopreventive potential of Tribulus terrestris against 7, dimethylbenz a anthracene induced skin papillomagenesis in mice.
Asian Pac J Cancer Prev. Apr-Jun ;7 2
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