They may decrease the benefits e. If an overdose occurs call your doctor or You may need urgent medical care. You may also contact the poison control center at A specific treatment to reverse the effects of aripiprazole does not exist. Headache, extrapyramidal symptoms, drowsiness, restlessness, fatigue, sedation, agitation, insomnia, anxiety, weight gain, cholesterol abnormalities, increased glucose, nausea, vomiting, constipation, application site rash MyCite , tremor.
Aripiprazole may increase the blood levels of a hormone called prolactin. Side effects of increased prolactin levels include females losing their period, production of breast milk and males losing their sex drive or possibly experiencing erectile problems. Long term months or years of elevated prolactin can lead to osteoporosis or increased risk of bone fractures. Some people may develop muscle-related side effects while taking aripiprazole. Symptoms of EPS include restlessness, tremor, and stiffness.
TD symptoms include slow or jerky movements that one cannot control, often starting in the mouth with tongue rolling or chewing movements. Temperature regulation: Impaired core body temperature regulation may occur; caution with strenuous exercise, heat exposure, and dehydration. Second generation antipsychotics SGAs increase the risk of weight gain, high blood sugar, and high cholesterol. This is also known as metabolic syndrome. Your healthcare provider may ask you for a blood sample to check your cholesterol, blood sugar, and hemoglobin A1c a measure of blood sugar over time while you take this medication.
Information on healthy eating and adding exercise to decrease your chances of developing metabolic syndrome may be found at the following sites:. SGAs have been linked with higher risk of death, strokes, and transient ischemic attacks TIAs in elderly people with behavior problems due to dementia.
All antipsychotics have been associated with the risk of sudden cardiac death due to an arrhythmia irregular heart beat. To minimize this risk, antipsychotic medications should be used in the smallest effective dose when the benefits outweigh the risks. Your doctor may order an EKG to monitor for irregular heartbeat. Symptoms include confusion, fever, extreme muscle stiffness, and sweating. If any of these symptoms occur, contact your healthcare provider immediately.
All antipsychotics can cause sedation, dizziness, or orthostatic hypotension a drop in blood pressure when standing up from sitting or lying down. These side effects may lead to falls which could cause bone fractures or other injuries. This risk is higher for people with conditions or other medications that could worsen these effects. If falls or any of these symptoms occur, contact your healthcare provider.
The U. Food and Drug Administration FDA is warning that compulsive or uncontrollable urges to gamble, binge eat, shop, and have sex have been reported with the use of aripiprazole. These uncontrollable urges were reported to have stopped when the medicine was discontinued or the dose was reduced.
These impulse-control problems are rare, but they may result in harm to the patient and others if not recognized. Tardive dyskinesia TD is a side effect that develops with prolonged use of antipsychotics. If you develop symptoms of TD, such as grimacing, sucking, and smacking of lips, or other movements that you cannot control, contact your healthcare provider immediately. All patients taking either first or second generation antipsychotics should have an Abnormal Involuntary Movement Scale AIMS completed regularly by their healthcare provider to monitor for TD.
Second generation antipsychotics SGAs increase the risk of diabetes, weight gain, high cholesterol, and high triglycerides. It is very important to tell your doctor how you feel things are going during the first few weeks after you start taking aripiprazole. It will probably take several weeks to see big enough changes in your symptoms to decide if aripiprazole is the right medication for you. Antipsychotic treatment is generally needed lifelong for persons with schizophrenia.
Your doctor can best discuss the duration of treatment you need based on your symptoms and illness. Both first generation typical and second generation atypical antipsychotics are associated with an increased risk of mortality in elderly patients when used for dementia related psychosis.
Although there were multiple causes of death in studies, most deaths appeared to be due to cardiovascular causes e. Antipsychotics are not indicated for the treatment of dementia-related psychosis.
Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. This risk may persist until significant remission occurs. Patients, their families, and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia.
All patients being treated with this medication for depression should watch for and notify their healthcare provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment.
Last Updated: January This information is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists.
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Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions. Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein. The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability alleged as a result of the information provided herein. Search Close Menu. Sign In About Mental Illness.
About Mental Illness Treatments. About Mental Illness Research. Your Journey Individuals with Mental Illness. Your Journey Family Members and Caregivers. Your Journey Identity and Cultural Dimensions. Your Journey Frontline Professionals. Get Involved Become a Fundraiser. And your thoughts may be racing, making it difficult for you to concentrate. During mixed episodes, you have manic symptoms and depression symptoms at the same time.
Symptoms of depression can include feeling sad or hopeless, or lacking interest in activities that you used to enjoy. Some people with depression may have suicidal thoughts or behaviors, which are serious and may be life threatening.
With mixed episodes, you can have large changes in your mood. In clinical trials , Abilify was effective in treating manic and mixed episodes of bipolar I disorder. Below, we present some of the results of these studies. Four different studies looked at treatment with Abilify compared with that of a placebo treatment with no active drug. Higher Y-MRS scores indicate worse mania symptoms than lower scores indicate. The studies showed that:. A clinical trial also compared treatment with Abilify plus either lithium or valproate to that of a placebo plus either lithium or valproate.
This trial showed that:. Abilify is approved to treat schizophrenia in adults and children ages 13 years and older. Many different things can cause schizophrenia. These include genetics and changes in certain neurotransmitters brain chemicals. Usually, schizophrenia begins to affect people during their teenage or young adult years.
Symptoms of schizophrenia vary, but they can include:. In clinical trials, Abilify was effective in treating schizophrenia. Test scores from this scale range from 30 to These studies showed that:. Abilify is approved to treat irritability related to autism in children ages 6 years and older. In addition to the uses listed above, Abilify may be prescribed off-label for other uses. And you may wonder if Abilify is used for certain other conditions. Below is information on other possible uses for Abilify.
Anxiety can refer to a range of conditions, which are explained in a bit more detail below. These conditions include:. Some studies have shown that Abilify may be a treatment option for certain people with anxiety. However, in some people, Abilify may actually cause symptoms of anxiety. So Abilify may not be right for everyone with anxiety. With GAD, you may feel restless or irritable. And you may have trouble falling or staying asleep.
This study showed that there may be a benefit from Abilify treatment in people with GAD. You may also have compulsions repetitive actions. For example, obsessions may include being afraid of germs or feeling that things need to be in a certain order.
Examples of compulsions may include constantly cleaning or repeatedly checking to make sure the oven is turned off. These obsessions and compulsions from OCD can cause anxiety. These other treatments may include drugs called selective serotonin reuptake inhibitors SSRIs.
So for this condition, your doctor may recommend that you take a low dose of Abilify along with an SSRI. And that event may cause flashbacks and nightmares that lead to anxiety. For example, people with trouble sleeping may be unable to drive or focus on tasks. One study showed that Abilify may help people with sleep disorders to fall asleep more quickly and to sleep better. Another study looked at why Abilify may work for people with sleep disorders.
Because Abilify can cause insomnia as a side effect, a dose of the medication during the day may help people stay awake. And this could cause them to feel tired at night and be able to sleep better.
But the drug is being studied for this use. You may also have hyperactivity, which makes you unable to stay still. ADHD may also affect your ability to focus and learn.
DMDD causes irritability, moodiness, and temper tantrums. In this study, people took Abilify along with methylphenidate Ritalin, Metadate. People with psychosis may have trouble figuring out what is real and what is imagined. A review was done to see if Abilify may be a treatment option for people with psychosis.
Abilify is still being studied for use in people with psychosis. If you have questions about using Abilify to treat psychosis, talk with your doctor. Abilify is approved for use in children with certain mental health conditions. Below, we describe the use of Abilify for these conditions.
Keep in mind that Abilify may increase the risk of suicidal thoughts and behaviors in children and young adults ages 24 and younger. Because of this risk, Abilify should be used cautiously in people ages 24 and younger. In clinical trials, Abilify was effective in treating schizophrenia in children ages 13 and older.
In a study, Abilify treatment was compared with that of a placebo treatment with no active drug. Test scores from this test range from 30 to Higher scores indicate worse schizophrenia symptoms than lower scores indicate. The study showed that:.
Abilify is approved to treat manic or mixed episodes related to bipolar I disorder in children ages 10 years and older. For this condition, Abilify is approved for use on its own. In clinical trials, Abilify was effective in treating manic and mixed episodes of bipolar I disorder in children.
One study looked at Abilify treatment compared with that of a placebo treatment with no active drug. Test scores from this scale range from 0 to Higher scores indicate worse mania symptoms than lower scores indicate. For this use, Abilify can be prescribed for children ages 6 years and older.
Autism symptoms vary across a spectrum. For example, some children with autism are able to function at a very high level, while other children with autism need more care. Autism is often diagnosed in children around the age of 2 years, when they may be having trouble with development. Specifically, Abilify is used to treat irritability in children with autism. Irritability includes symptoms such as tantrums, injuring yourself, or having aggressive behaviors. Two different studies looked at Abilify treatment compared with that of a placebo treatment with no active drug.
ABC test scores from this scale range from 0 to Higher ABC test scores indicate worse irritability symptoms than lower scores do. It causes involuntary movements and sounds that happen repetitively. These movements and sounds are also called tics. Examples of movement-related tics include repetitive eye blinking or head jerking. Examples of sound-related tics include those that affect speech, such as repeating things that other people are saying.
In some cases, tics can be dangerous. In fact, sometimes tics may cause a person to hurt themselves. It often improves and may even disappear as people age into adulthood.
The TTS scale ranges from 0 to Higher TTS scores indicate worse tic symptoms than lower scores indicate. For some of its approved uses, Abilify may be used in combination with other drugs.
However, when treating major depressive disorder MDD , Abilify is always used with other drugs. MDD is also simply called depression. For MDD, Abilify is approved as an adjunct treatment. Adjunct treatments are used in combination with other drugs to treat certain conditions.
So as an adjunct treatment for MDD, Abilify is only used with other drugs. Below, we describe some of the drugs that may be used with Abilify. Or your doctor may change your medication regimen altogether.
If you have questions about using medications with Abilify, talk with your doctor. They can recommend an appropriate treatment plan for your condition. Your doctor may prescribe Abilify along with antidepressants to treat your condition. Some examples of antidepressants that may be taken with Abilify include:. Your doctor may prescribe Abilify along with mood stabilizers to treat your condition. Some examples of mood stabilizers that may be taken with Abilify include:.
Your doctor may prescribe Abilify along with stimulants to treat your condition. Some examples of stimulants that may be taken with Abilify include:. Your doctor may prescribe Abilify along with other antipsychotic drugs to treat your condition. Some examples of other antipsychotics that may be taken with Abilify include:. Other drugs are available that can treat your condition. Some may be a better fit for you than others. They can tell you about other medications that may work well for you.
Note: Some of the drugs listed below are used off-label to treat these specific conditions. This means that Abilify is only used with other drugs for MDD. Examples of other drugs that may be used to treat manic and mixed episodes related to bipolar I disorder include:. Examples of other drugs that may be used to treat schizophrenia include:. You may wonder how Abilify compares with other medications that are prescribed for similar uses. Here we look at how Abilify and Abilify Maintena are alike and different.
Both Abilify and Abilify Maintena contain the same active drug: aripiprazole. But even though these medications contain the same active drug, they act slightly differently inside your body. Abilify Maintena is approved to treat schizophrenia in adults. The typical dosage of this drug is mg given once each month. Because Abilify and Abilify Maintena both contain the same active drug, their mild and serious side effects are the same. Also, because Abilify Maintena is an injectable medication, you may have pain at your injection site after receiving a dose of the drug.
In some cases, you may actually start out by taking Abilify. Then if your condition responds well to the drug, you may start taking Abilify Maintena instead. One study looked at people who took Abilify and then transitioned to Abilify Maintena. These people had more benefit in decreasing their schizophrenia symptoms when they switched to Abilify Maintena. But separate studies have found both Abilify and Abilify Maintena to be effective in treating schizophrenia.
According to estimates on GoodRx. The cost also depends on whether you receive doses of either drug from a pharmacy or a medical facility. Abilify and Abilify Maintena are both brand-name drugs. Brand-name medications usually cost more than generics cost. Like Abilify Maintena, discussed above, other medications are also prescribed for similar uses as Abilify is. Here we look at how Abilify and Rexulti are alike and different.
Abilify contains the active drug aripiprazole , while Rexulti contains the active drug brexpiprazole. Both Abilify and Rexulti are approved to treat schizophrenia. For this use, Abilify can be prescribed for adults and children ages 13 years and older.
However, Rexulti is only approved for use in adults. Abilify and Rexulti are also both approved for use in adults as adjunct treatments for major depressive disorder MDD , which is also simply called depression. Abilify and Rexulti both contain medications that treat schizophrenia and MDD.
Therefore, these medications can cause very similar side effects, but some different ones as well. Below are examples of these side effects. These lists contain up to 10 of the most common mild side effects that can occur with Abilify, with Rexulti, or with both drugs when taken individually. These lists contain examples of serious side effects that can occur with Abilify, with Rexulti, or with both drugs when taken individually.
And these medications can also each be used in combination with other drugs to treat MDD. The use of Abilify and Rexulti in treating schizophrenia has been directly compared in a clinical study. Abilify and Rexulti are both brand-name drugs. There is currently a generic form of Abilify, called aripiprazole. Brand-name medications usually cost more than generics. Like Rexulti, discussed above, other medications are prescribed for similar uses as Abilify is.
Here we look at how Abilify and Latuda are alike and different. Abilify contains the active drug aripiprazole , while Latuda contains the active drug lurasidone. Both Abilify and Latuda are approved to treat schizophrenia in adults and children ages 13 years and older. Abilify and Latuda both contain drugs to treat schizophrenia. These lists contain up to 10 of the most common mild side effects that can occur with Abilify, with Latuda, or with both drugs when taken individually. These lists contain examples of serious side effects that can occur with Abilify, with Latuda, or with both drugs when taken individually.
But separate studies have found both Abilify and Latuda to be effective in treating schizophrenia. Abilify and Latuda are both brand-name drugs. Controlled substances are more likely than other medications to cause dependence. With dependence, your body needs the drug in order to feel normal.
Abilify may cause dependence because it affects hormones inside your brain. And once your body adjusts to the changes caused by Abilify, you may become dependent on the drug. However, keep in mind that dependence of Abilify has not been studied in humans. Because this medication may cause dependence and withdrawal symptoms, your doctor may recommend a different medication for you that has a lower risk of these complications.
His symptoms included dizziness, nausea, anxiety, and muscle twitches. He also had insomnia trouble falling asleep or staying asleep. But keep in mind that this case only involved one person. If you have questions about withdrawal symptoms from Abilify, talk with your doctor or pharmacist. With tapering, your doctor will slowly decrease your dose of the drug so that your body can adjust to the lower dose over time. Tapering off of Abilify can help decrease your risk of withdrawal symptoms.
Keep in mind that the lowest dose that Abilify tablets are made in is 2 mg. Abilify affects the levels of two brain chemicals called dopamine and serotonin. Serotonin is important in controlling your mood and behavior. Dopamine is important in regulating how you think and feel.
And Abilify is approved to treat each of these conditions. Abilify may work to treat certain mental health conditions by balancing dopamine and serotonin levels. They can recommend whether you need medical attention. Yes, sometimes Abilify is used off-label to treat anxiety.
And if you have questions about whether Abilify may be helpful in treating your anxiety, talk with your doctor. Yes, Abilify may cause you to have dangerous impulses or urges. But all of these urges can be harmful, so you should tell your doctor, a family member, or a friend if you notice any impulses. In addition, your family and friends should also be keeping an eye out for any new impulses you may develop.
This is important for them to do because you might not notice certain urges developing. As soon as any urges or impulses are noticed, your doctor will likely decrease your dosage of Abilify. Or your doctor may have you stop taking the medication altogether. They can discuss with you the risks and benefits of treatment. These brain chemicals include dopamine and serotonin. And serotonin is important in controlling your mood and behavior.
Abilify may work by balancing your dopamine and serotonin levels. No, you should never take Abilify by snorting the drug. Abilify is meant to be taken by mouth. However, when you snort a drug through your nose, the drug goes directly into your bloodstream. In addition, snorting drugs can cause problems inside your nose, such as swelling or infections. And in some cases , snorting drugs can even cause a hole to form between your nostrils.
If you have questions about the best way to take your doses of Abilify, talk with your doctor or pharmacist. Yes, sometimes Abilify is used off-label to treat bipolar II disorder. On the other hand, Abilify is approved to treat manic or mixed episodes related to bipolar I disorder. During these episodes, you can feel very energetic or extremely irritable. With mixed episodes, you have both manic symptoms and depression symptoms at the same time.
This causes large changes in your mood. However, with bipolar II disorder, your most common symptom is major depression. Because people with bipolar II disorder mostly have depressive symptoms, Abilify may not work as well for them. If you have questions about using Abilify to treat bipolar II disorder, talk with your doctor. They can recommend whether Abilify may be an option to treat your condition.
In fact, for some people, Abilify may actually make them feel more sleepy than usual. Some drugs called stimulants may make you feel more energetic than usual. Abilify belongs to a class of drugs called antipsychotics. A drug class describes a group of medications that work in the same way. Specifically, Abilify is a second-generation antipsychotic.
Second-generation antipsychotics are a newer class of antipsychotic drugs. They cause fewer side effects than the first-generation antipsychotics do. Because there are many different mood disorders, there are also many different drug classes used to treat them. For example, mood stabilizers, such as lithium , are drugs that help make your mood more consistent. In addition, Abilify is also not an antidepressant medication. Examples of antidepressants that are used with Abilify include:.
Controlled substances are more likely than other drugs to cause dependence and withdrawal. So you may have some symptom relief in the first day or so after your first dose of Abilify. Alcohol may cause dizziness, sleepiness, or trouble focusing. It may also decrease your blood pressure. Abilify can also cause these same side effects.
Drinking alcohol and taking Abilify may increase your risk of these side effects. Using more than the recommended dosage of Abilify can lead to serious side effects. Do not use more Abilify than your doctor recommends. In clinical trials , both intentional and accidental overdoses of Abilify in children and adults did occur.
You can also call the American Association of Poison Control Centers at or use their online tool. But if your symptoms are severe, call or go to the nearest emergency room right away. Abilify can interact with several other medications. It can also interact with certain foods. Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works.
Other interactions can increase side effects or make them more severe. Below are lists of medications that can interact with Abilify. Before taking Abilify, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.
If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Abilify may interact with drugs that belong to a class of medications called benzodiazepines. A class of drugs describes a group of medications that work in the same way. Both Abilify and benzodiazepines can cause tiredness. Taking Abilify with a benzodiazepine may worsen these effects. In some cases, your doctor may recommend that you take Abilify along with a benzodiazepine.
However, because of the increased risk of side effects when doing this, your doctor will monitor your blood pressure. If needed, your doctor may adjust your dosage of either Abilify or the benzodiazepine drug. Doing this can help to lower your risk of side effects.
If you have any questions about the interactions between Abilify and benzodiazepines, talk with your doctor or pharmacist. Abilify may interact with certain antidepressant drugs. And Abilify may sometimes be used in combination with an antidepressant for other conditions as well.
This way, your doctor can determine if there are any drug interactions that may affect you. Specifically, Abilify may interact with certain antidepressants that belong to a class of drugs called selective serotonin reuptake inhibitors SSRIs.
Taking either of these drugs with Abilify may increase the level of Abilify in your body. And this could increase your risk of side effects from Abilify. If you have questions about interactions between Abilify and certain antidepressants, talk with your doctor or pharmacist. Abilify is broken down in your liver by enzymes certain proteins. Taking Abilify with any drugs that affect these enzymes can alter the level of Abilify in your body.
In some cases, the level will be increased, but in other cases, it will be decreased. Below, we describe these possible interactions with Abilify. If you have any questions about which drugs may interact with Abilify, talk to your doctor or pharmacist. When this occurs, the level of Abilify in your body will be increased.
And you may have an increased risk of side effects from Abilify. Some medications induce prompt CYP3A4 to work faster than usual. When this occurs, the level of Abilify in your body will be decreased.
And in this case, Abilify may not work as well to treat your condition. Abilify may interact with certain blood pressure medications , causing your blood pressure to become too low.
This effect happens because Abilify can also decrease your blood pressure. The combination of Abilify with a blood pressure medication can even cause very low blood pressure that may become dangerous. Abilify can interact with some recreational drugs, which may increase your risk of side effects from Abilify.
In addition, pain medications may also interact with Abilify. In these cases, the pain medications would be considered recreational. Examples of pain medications that are sometimes used recreationally include:.
All of the recreational drugs listed above may cause your heart rate to be slower than usual. These drugs may also cause decreased blood pressure , sleepiness, and slowed breathing. Abilify can also decrease your blood pressure and cause sleepiness. So taking recreational drugs with Abilify may increase your risk of these side effects.
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